A Highly Efficient Carbon-Carbon Bond Formation Reaction via Nucleophilic Addition to N-Alkylaldimines without Acids or Metallic Species
Hisao Nemoto,* Tomoyuki Kawamura and Norikazu Miyoshi
*Department of Molecular Design and Synthesis, Division of Pharmaceutical
Chemistry, Institute of Health Biosciences, The University of Tokushima, 1-78,
Sho-machi, Tokushima 770-8505, Email: nem
ph.tokushima-u.ac.jp
H. Nemoto, T. Kawamura, N. Miyoshi, J. Am. Chem. Soc., 2005, 127, 14546-14547.
DOI: 10.1021/ja054010h (free Supporting Information)
Abstract
A nucleophilic acid-free addition of dicyanomethyl acetate to N-methylaldimines gives α-(N-methyl-N-acetyl)amino acid methyl esters in excellent yield.
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Key Words
ID: J48-Y2005-2620
