Microwave-Assisted Flexible Synthesis of 7-Azaindoles
Hartmut Schirok
*Bayer HealthCare AG, Pharma Research, D-42096 Wuppertal, Germany, Email:
hartmut.schirok
bayerhealthcare.com
H. Schirok, J. Org. Chem., 2006, 71, 5538-5545.
DOI: 10.1021/jo060512h (free Supporting Information)
Abstract
A robust and flexible synthesis of 1,3- and 1,3,6-substituted 7-azaindoles is presented starting from nicotinic acid derivatives or 2,6-dichloropyridine, respectively. Microwave heating dramatically accelerates the penultimate reaction step, an epoxide-opening-cyclization-dehydration sequence.
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relative reactivities
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Key Words
azaindoles, microwave synthesis, Suzuki coupling
ID: J42-Y2006-2110
