Practical Synthesis of Aryl Triflates under Aqueous Conditions
Doug E. Frantz*, Damian G. Weaver, James P. Carey, Michael H. Kress and Ulf H. Dolling
*Department of Process Research, Merck Laboratories, Merck & Co., 466 Devon
Park Drive, Wayne, Pennsylvania 19087, Email: doug_frantz
merck.com
D. E. Frantz, D. G. Weaver, J. P. Carey, M. H. Kress, U. H. Dolling, Org. Lett., 2002, 4, 4717-4718.
DOI: 10.1021/ol027154z (free Supporting Information)
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Abstract
A simple and efficient synthesis of aryl triflates under biphasic conditions is described which omits the use of amine bases and allows facile isolation by simple solvent evaporation after phase separation. Good yields can also be obtained without the use of organic solvent.
Stereoselective Synthesis of Acetoacetate-Derived Enol Triflates
D. Babinski, I. Soltani, D. E. Frantz, Org. Lett., 2008, 10, 2901-2904.
Key Words
Schotten-Baumann conditions, triflic anhydrid, triflates
ID: J54-Y2002-280
