Facile Cleavage of Silyl Protecting Groups with Catalytic Amounts of FeCl₃

Yong-Qing Yang, Jia-Rong Cui, Lin-Gui Zhu, Ya-Ping Sun, Yikang Wu*

*State Key Laboratory of Bioorganic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, P. R. of China, Email: yikangwumail.sioc.ac.cn

Y.-Q. Yang, J.-R. Cui, L.-G, Zhu, Y.-P. Sun, Y. Wu, Synlett, 2006, 1260-1262.

DOI: 10.1055/s-2006-926256

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Abstract

A very mild and environmentally benign method for the removal of silyl protecting groups using catalytic amounts of iron in MeOH is particularly effective for cleaving triethylsilyl (TES) groups.

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Key Words

deprotection, hydrolysis, removal, cleavage, iron ion

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ID: J60-Y2006-4390