Periodic Acid

Recent Literature

Benzyl alcohols and benzyl TBDMS ethers were efficiently oxidized to the corresponding carbonyl compounds in high yield with periodic acid catalyzed by CrO₃ at low temperature (-78 °C). The oxidation procedure was highly functional group tolerant and very selective for the TBDMS group over the TBDPS group.
S. Zhang, L. Xu, M. L. Trudell, Synthesis, 2005, 1757-1760.

S. Zhang, L. Xu, M. L. Trudell, Synthesis, 2005, 1757-1760.

A CrO₃-catalyzed oxidation of primary alcohols to carboxylic acids proceeds smoothly with only 1-2 mol % of CrO₃ and 2.5 equivalents of H₅IO₆ in wet MeCN to give the carboxylic acids in excellent yield. No significant racemization is observed for alcohols with adjacent chiral centers. Secondary alcohols are cleanly oxidized to ketones.
M. Zhao, J. Li, Z. Song, R. Desmond, D. M. Tschaen, E. J. J. Grabowski, P. J. Reider, Tetrahedron Lett., 1998, 39, 5323-5326.

A facile and quantitative preparation of carboxylic acids by a pyridinium chlorochromate (PCC) catalyzed (2 mol%) oxidation of primary alcohols and aldehydes using 2.2 equivalents and 1.1 equivalents of H₅IO₆, respectively, in acetonitrile is described here.
M. Hunsen, Synthesis, 2005, 2487-2490.

M. Hunsen, Synthesis, 2005, 2487-2490.

An excellent method for the selective oxidation of sulfides to sulfoxides with periodic acid (H₅IO₆) catalyzed by FeCl₃ in MeCN has been devised. The reported procedure is fast, simple and the yields are excellent in most cases with reaction time of less than 2 minutes.
S. S. Kim, K. Nehru, S. S. Kim, D. W. Kim, H. C. Jung, Synthesis, 2002, 2484-2486.

Bromination of alkenes, alkynes, and anilines has efficiently been carried out at room temperature in short reaction times using potassium bromide and orthoperiodic acid in dichloromethane-water (1:1) to prepare the corresponding brominated compounds with excellent yields.
A. Khazaei, M. A. Zolfigol, E. Kolvari, N. Koukabia, H. Soltania, F. Komakia, Synthesis, 2009, 3672-3676.