Manganese
Name Reactions
Recent Literature
An efficient, nickel-catalyzed direct reductive cross-coupling of equimolar
amounts of alkyl halides with aryl halides in the presence of manganese is
generally high-yielding, highly functional-group-tolerant, and easy to perform.
The reaction appears to avoid the formation of intermediate organomanganese
species, and a synergistic effect was found when a mixture of two ligands was
employed.
D. A. Everson, R. Shrestha, D. J. Weix, J. Am. Chem. Soc., 2010,
132, 920-921.
A generally applicable, sequential reaction of dichloroesters with various
aldehydes is promoted by active manganese to give α,β-unsaturated esters with
complete control of stereoselectivity. The C-C double bond can be di- or
trisubstituted. A mechanism based on a successive aldol-type reaction/-elimination
is proposed.
J. M. Concellón, H. Rodríquez-Solla, P. Díaz, R. Llaona, J. Org. Chem., 2007,
72, 4396-4400.
A complete E-selective synthesis of α,β-unsaturated amides through a
sequential reaction of a range of dichloroamides with a variety of aldehydes is
promoted by Rieke manganese (Mn*). The unsaturated amides obtained are readily
and efficiently transformed into α,β-unsaturated ketones, aldehydes, or
carboxylic acids.
J. M. Concellón, H. Rodríquez-Solla, P. Díaz, J. Org. Chem., 2007,
72, 7974-7979.
Stereoselective β-elimination of diastereomeric mixtures of
2-bromo-3-hydroxyesters is achieved by using unactivated manganese and
trimethylsilyl chloride, to yield (E)-α,β-unsaturated esters with total
diastereoselectivity.
J. M. Concellón, H. Rodríguez-Solla, V. del Amo, Synlett,
2006, 315-317.
A totally regioselective transformation of aromatic N-4-methoxyphenylaziridine
2-carboxamides into 2-aminoamides is promoted by active manganese (Mn*). α-Amino
ketones can be readily obtained by reaction of morpholine-derived 2-aminoamides
with organolithium compounds.
J. M. Concellón, H. Rodríguez-Solla, V. del Amo, P. Díaz, J. Org. Chem., 2010,
75, 2407-2410.
