Categories: C-C Bond Formation > Arenes, Cyclic Compounds >
Synthesis of indenones
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Recent Literature
In the presence of a rhodium catalyst, paraformaldehyde enables a CO gas-free
carbonylative cyclization of alkynes with 2-bromophenylboronic acids to yield
indenone derivatives. Rhodium-catalyzed decarbonylation of formaldehyde is
followed by carbonylation of alkynes with 2-haloboronic acids, respectively,
leading to efficient whole carbonylation.
T. Morimoto, K. Yamasaki, A. Hirano, K. Tsutusmi, N. Kagawa, K. Kakiuchi, Y.
Harada, Y. Fukukomoto, N. Chatani, T. Nishioka, Org. Lett., 2009,
11, 1777-1780.
A facile, efficient, and large-scale strategy for the synthesis of N-(1-Oxo-1H-inden-2-yl)benzamide
derivatives via domino reaction between aryl aldehydes, hippuric acid, and
acetic anhydride is catalyzed by HPW@nano-SiO2 under microwave
irradiation. The reaction conditions are very simple and offer convenient
isolation of the product. Moreover, the catalyst can be re-used up to five times
after simple filtration.
M. Rostami, A. R. Khosropour, V. Mirkhani, I. Mohammadpoor-Baltork, M. Moghadam,
S. Tangestaninejad, Synlett, 2011,
1677-1682.
