Categories: C-C Bond Formation > Nitrogen-containing molecules >
Synthesis of Nitriles
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Name Reactions
Recent Literature
An efficient cobalt-catalyzed reductive coupling reaction of alkyl halides
with alkenes bearing electron-withdrawing groups in the presence of water
and zinc powder in acetonitrile gave the corresponding Michael-type addition
products in high yields. The mechanism is discussed.
P. Shukla, Y.-C. Hsu, C.-H. Cheng, J. Org. Chem.,
2006,
71, 655-658.
The ionic liquid [bmIm]OH is a catalyst and a reaction medium for Michael
additions. Although the addition to α,β-unsaturated ketones gives the
monoaddition products, this ionic liquid always drives the reaction of
open-chain 1,3-dicarbonyl compounds with α,β-unsaturated esters and nitriles
toward bis-addition.
B. C. Ranu, S. Banerjee, Org. Lett., 2005,
7, 3049-3052.
