Categories: C-Cl Bond Formation >
Synthesis of α-chlorocarboxylic acids and derivatives
Recent Literature
Asymmetric hydration of α,α-dichloro aldehydes and α-halo enals via a
NHC-catalyzed redox process gives enantioenriched α-chloro and α-fluoro
carboxylic acids. The reaction allows the installation of an α-deuterium to give
α-deutero α-halo acids using D2O as the deuteron source.
H. U. Vora, T. Rovis, J. Am. Chem. Soc., 2010,
132, 2860-2861.
