Categories: C-Cl Bond Formation >
Synthesis of 1,2-dichloroalkanes
Recent Literature
A stereospecific triphenylphosphine oxide-catalyzed 1,2-dichlorination reaction
of epoxides is effective for a range of terminal and internal epoxides. In
contrast to the classical Appel-type dichlorination of epoxides, oxalyl chloride
is used as a stoichiometric reagent to generate the chlorophosphonium salt
responsible for dichlorination from catalytic triphenylphosphine oxide.
R. M. Denton, X. Tang, A. Przeslak, Org. Lett., 2010,
12, 4678-4681.
