Categories: C-H Bond Formation >
Decyanations
Recent Literature
A rhodium-catalyzed reductive cleavage of carbon-cyano bonds using hydrosilane
as a mild reducing agent allows the decyanation of a wide range of nitriles,
including aryl, benzyl, and β-hydrogen containing alkyl cyanides. The use of
benzyl cyanide as a benzyl anion equivalent and the use of a cyano group as a
removable ortho-directing group are demonstrated.
M. Tobisu, R. Nakamura, Y. Kita, N. Chatani, J. Am. Chem. Soc., 2008,
131, 3174-3175.
