Categories: C-O Bond Formation > Synthesis of carboxylic acids >
Synthesis of carboxylic acids by oxidative cleavages and rearrangements
Name Reactions
Recent Literature
A facile synthesis of aryl carboxylic acids from aryl ketones by aerobic
photooxidation using the inexpensive and easily handled CBr4 as
catalyst is applicable to inert compounds under usual photo-irradiation
conditions, and appears very attractive for the expansion of the Norrish Type I
reaction.
S.-i. Hirashima, T. Nobuta, N. Tada, A. Itoh, Synlett, 2009,
2017-2019.
A catalytic, asymmetric conjugate addition of carbamates to enoyl systems provides a highly enantioselective two-step
access to N-protected β-amino acids.
C. Palomo, M. Oiarbide, R. Halder, M. Kelso, E. Gómez-Bengoa, J. García, J. Am. Chem. Soc.,
2004,
126, 9188-9189.
A mild, fast protocol for the conversion of β-ketoesters and β-diketones to
carboxylic acids with use of CAN in CH3CN is described. The
method is compatible with a number of functional groups, and can generate
carboxylic acids under neutral conditions. The mechanism is discussed.
Y. Zhang, J. Jiao, R. A. Flowers, II, J. Org. Chem., 2006,
71, 4516-4520.
D. Yang, C. Zhang, J. Org. Chem., 2000, 66, 4814-4818.
