Categories: Synthesis of N-Heterocycles, Synthesis of O-Heterocycles >
Synthesis of 1,2,4-oxadiazoles
Recent Literature
PTSA-ZnCl2 is an efficient and mild catalyst for the synthesis of
3,5-disubstituted-1,2,4-oxadiazoles from amidoximes and organic nitriles.
J. K. Augustine, V. Akabote, S. G. Hegde, P. Alagarsamy, J. Org. Chem., 2009,
74, 5640-5643.
A one-pot reaction between nitriles, hydroxylamine and Meldrum’s acids under
microwave irradiation and solvent-free conditions gives 3,5-disubstituted
1,2,4-oxadiazoles in good to excellent yields.
M. Adib, M. Mahdavi, N. Mahmoodi, H. Pirelahi, H. R. Bijanzadeh, Synlett, 2006,
1765-1767.
A series of α-amino acid-derived 1,2,4-oxadiazoles have been synthesized via a
convenient and inexpensive one-pot protocol in good yields and in relatively
short reaction times.
A. L. Braga, D. S. Lüdtke, E. E. Alberto, L. Dornelles, W. A. Severo Filho, V.
A. Corbellini, D. M. Rosa, R. S. Schwab, Synthesis, 2004,
1589-1594.
