Categories: Synthesis of O-Heterocycles >
Synthesis of 2-pyrones
Recent Literature
An electrophilic pyrone derivative, which can be readily prepared on a multigram
scale, undergoes metal-catalyzed cross-coupling reactions with a variety of
nucleophiles to yield 3-substituted-2-pyrones.
F. Frébault, M. T. Oliveira, E. Wöstefeld, Nuno Maulide, J. Org. Chem., 2010,
75, 762-7695.
Sequential alkyne activation of terminal alkynes and propiolic acids by gold(I)
catalysts yields α-pyrones in good yields. Novel cascade reactions involving
propiolic acids are reported that give rise to α-pyrones with different
substitution patterns.
T. Luo, M. Dai, S.-L. Zheng, S. L. Schreiber, Org. Lett., 2011,
13, 2834-2836.
A gold(I)-catalyzed rearrangement of β-alkynylpropiolactones enables a
straightforward synthesis of substituted α-pyrones in good yields.
T. Dombray, A. Blanc, J.-M. Weibel, P. Pale, Org. Lett., 2010,
12, 5362-5365.
Addition of a catalytic amount of Cy2NH·HX improves the rate and
yields for cyclization reactions of o-(alkynyl)benzoates in the presence
of a stoichiometric amount of copper(II)halide to give 4-haloisocoumarins. Under
the standard reaction conditions, various 4-haloisocoumarins are provided in
good yield.
Y. Liang, Y.-X. Xie, J.-H. Li, Synthesis, 2007,
400-406.
