Categories: Synthesis of O-Heterocycles >
Synthesis of Chromones and Flavones
Recent Literature
A Pd-catalyzed copper-free carbonylative Sonogashira coupling reaction at
room temperature was achieved
by using water as a solvent
under balloon pressure of CO with Et3N as a base. The developed method was
successfully applied to the synthesis of flavones.
B. Liang, M. Huang, Z. You, Z. Xiong, K. Lu, R. Fathi, J. Chen, Z. Yang, J. Org. Chem., 2005, 70, 6097-6100.
A mild ICl-induced cyclization of heteroatom-substituted alkynones provides
a simple, highly efficient approach to various 3-iodochromones,
iodothiochromenones, iodoquinolinones and analogues in good to excellent
yields. Subsequent palladium-catalyzed transformations afford a rapid
increase in molecular complexity.
C. Zhou, A. V. Dubrovsky, R. C. Larock, J. Org. Chem., 2006, 71, 1728-1731.
