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Synthesis of phthalides

Recent Literature

A palladium-catalyzed arylation of aldehydes with organoboronic acids gave 3-arylphthalides in good to excellent yields with high substrate tolerance in the presence of a thioether-imidazolinium carbene ligand.
M. Kuriyama, N. Ishiyama, R. Shimazawa, R. Shirai, O. Onomura, J. Org. Chem., 2009, 74, 9210-9213.

A new diamine ligand for Ru-catalyzed asymmetric transfer hydrogenation (ATH) enabled a highly enantioselective reduction of 2-acylarylcarboxylates. Subsequent in situ lactonization under aqueous conditions provided efficient access to a various 3-substituted phthalides in enantiomerically pure form.
B. Zhang, M.-H. Xu, G.-Q. Lin, Org. Lett., 2009, 11, 4712-4715.