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Synthesis of tetrahydroisoquinolines

Recent Literature

Microwave-assisted Bischler-Napieralski or Pictet-Spengler reactions allowed the production of substituted isoquinoline libraries. The generated dihydroisoquinolines and tetrahydroisoquinolines could be oxidized to their corresponding isoquinoline analogues. A more practical and efficient route to C1- and C4-substituted isoquinolines involves the preparation and activation of isoquinolin-1(2H)-ones.
E. Awuah, A. Capretta, J. Org. Chem., 2010, 75, 5627-5634.