Chemical modification of the adenine ring: Utilization of an N-alkoxy group as a control synthon.

T. Fujii, T. Itaya, Reviews on Heteroatom Chemistry, 1997, 16, 257.

Key Words:
adenine ring-opening/Dimroth rearrangement 1-alkoxyadenine/N-alkoxyadenine alkylation/adenine N-x,N-y-disubstituted adenosine N-alkyl/2'-deoxyadenosine N-methyl/imidazole carboxamidine/azepinomycin synthesis/NUCLEAR-MAGNETIC-RESONANCE/BASE-CATALYZED CONVERSION/DIMROTH REARRANGEMENT/REGIOSELECTIVE ALKYLATION/ALTERNATIVE SYNTHESIS/7,9-DIALKYLADENINIUM SALTS/HYDROLYTIC DEAMINATION/GLYCOSIDIC HYDROLYSIS/RIBOFURANOSYL GROUP/PURINES



Five n(x)-methyladenines: Their chemistry, physicochemical properties, and biological activities.

T. Fujii, T. Itaya, Heterocycles, 1998, 48, 1673.

Key Words:
NUCLEIC-ACID BASES/HUMAN 3-METHYLADENINE-DNA GLYCOSYLASE/MAGNETIC-RESONANCE SPECTROSCOPY/SPONGE AGELAS-MAURITIANA/N-SUBSTITUTED ADENINES/MARINE SPONGE/PURINE-BASES/ALTERNATIVE SYNTHESIS/INFRARED-SPECTRA/COORDINATION CHEMISTRY



The Dimroth rearrangement in the adenine series: A review updated.

T. Fujii, T. Itaya, Heterocycles, 1998, 48, 359.

Key Words:
NUCLEAR-MAGNETIC-RESONANCE/M-CHLOROPEROXYBENZOIC ACID/BASE-CATALYZED CONVERSION/ANEMONE PURINE CAISSARONE/CALF THYMUS DNA/HYDROLYTIC DEAMINATION/RING FISSION/NITROGEN-15-LABELED DEOXYNUCLEOSIDES/7,9-DIALKYLADENINIUM SALTS/REGIOSELECTIVE ALKYLATION



The 11 positional isomers of N-x,N-y-dimethyladenine: Their chemistry, physicochemical properties, and biological activities.

T. Fujii, T. Itaya, Heterocycles, 1999, 51, 393.

Key Words:
NUCLEIC-ACID BASES/GLYCOSIDIC BOND-CLEAVAGE/PRESSURE LIQUID-CHROMATOGRAPHY/GERMINAL VESICLE BREAKDOWN/SPONGE AMPHIMEDON VIRIDIS/ANEMONE PURINE CAISSARONE/PROTEIN-KINASE INHIBITORS/AGELAS-NAKAMURAI HOSHINO/VARICELLA-ZOSTER VIRUS/N-METHYLATED ADENINES



The chemistry of N-x, N-y, N-z-trimethyladenines and more highly N-methylated adenines.

T. Fujii, T. Itaya, Heterocycles, 1999, 51, 1141.

Key Words:
SEA-ANEMONE PURINE/NUCLEIC-ACID BASES/ISOMERIC OH ADDUCTS/AQUEOUS-SOLUTIONS/BUNODOSOMA-CAISSARUM/ADENOCARCINOMA CA755/RADICAL REACTION/DERIVATIVES/ANALOGS/N-6-METHYLADENINE



Systematic tables of mono- and poly-N-methylated adenines: Acid dissociation constants and UV and NMR spectral data.

T. Fujii, T. Itaya, Heterocycles, 1999, 51, 2255.

Key Words:
NUCLEAR-MAGNETIC-RESONANCE/REGIOSELECTIVE ALKYLATION/7,9-DIALKYLADENINIUM SALTS/9-SUBSTITUTED PURINES/DIMROTH REARRANGEMENT/BIOLOGICAL-ACTIVITIES/ALTERNATIVE SYNTHESIS/STACKING INTERACTIONS/SELF-ASSOCIATION/CONTROL SYNTHON



N-x-oxygenated adenines: Their chemistry, physico-chemical properties, and biological activities.

T. Fujii, T. Itaya, Heterocycles, 1999, 51, 1971.

Key Words:
YEAST SACCHAROMYCES-CEREVISIAE/BASE ANALOG 6-N-HYDROXYLAMINOPURINE/ENHANCED INDUCED MUTAGENESIS/FORWARD-MUTATION TEST/SALMONELLA-TYPHIMURIUM/ASPERGILLUS-NIDULANS/ESCHERICHIA-COLI/GENETIC-ACTIVITY/MOLYBDENUM OXOTRANSFERASES/DIMROTH-REARRANGEMENT



The 7-N-oxides of purines related to nucleic acids: Their chemistry, synthesis, and biological evaluation.

T. Fujii, T. Itaya, K. Ogawa, Heterocycles, 1997, 44, 573.

Key Words:
GUANINE 7-N-OXIDE/ADENINE 7-OXIDE/STREPTOMYCES-PURPURASCENS/ANTILEUKEMIC ACTIVITY/ALTERNATIVE SYNTHESIS/N-OXIDES/7-HYDROXYGUANINE/DERIVATIVES/OXIDATION/NUCLEOSIDES



1'-methyl-trans-zeatin and its analogues: Their occurrence, chemistry and synthesis, and cytokinin activity.

T. Fujii, T. Itaya, M. Ohba, Heterocycles, 1997, 46, 659.

Key Words:
PLANT PATHOGENIC PSEUDOMONADES/SYRINGAE PV SAVASTANOI/2'-DEOXYZEATIN RIBOSIDE/1'-METHYLZEATIN/PURINES/9-BETA-D-RIBOFURANOSIDE/ZEATIN/BIOSYNTHESIS/ENANTIOMERS



Racemic and chiral syntheses of some indolo[2,3-a]quinolizidine alkaloids through a ''lactim ether route''.

T. Fujii, M. Ohba, Heterocycles, 1998, 47, 525.

Key Words:
BENZO<A>QUINOLIZIDINE-TYPE ALANGIUM ALKALOIDS/STEREOSELECTIVE TOTAL SYNTHESIS/OPHIORRHIZA-MAJOR RIDL/INDOLE ALKALOIDS/ASYMMETRIC-SYNTHESIS/ASPIDOSPERMA-MARCGRAVIANUM/ABSOLUTE-CONFIGURATION/ETHYL CINCHOLOIPONATE/NEISOSPERMA-GLOMERATA/CONVENIENT SYNTHESIS



T. Fujii, M. Ohba, in The Alkaloids, Vol. 51 (Ed.: G. A. Cordell), Academic Press, San Diego, CA, 1998.

Key Words:



Chiral Synthesis of Benzo[a]quinolizidine-Type Apangium Alkaloids.

T. Fujii, M. Ohba, S. Yoshifuji, Heterocycles, 1988, 27, 1009.

Key Words:
TARGET SYNTHESIS/ALKALOIDS/HETEROCYCLES/LACTIM ETHER