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Synthesis of Macrolides.

K. C. Nicolaou, Tetrahedron, 1977, 33, 683.

Key Words:
TARGET SYNTHESIS/MACROLIDES



Chemical synthesis of Glycosphingolipids.

K. C. Nicolaou, Chemtracts: Organic Chemistry, 1991, 4, 181.

Key Words:
TARGET SYNTHESIS/MISCELLANEOUS



New synthetic methods and strategies and total synthesis of natural products.

K. C. Nicolaou, Aldrichimica Acta, 1993, 26, 63.

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The battle of calicheamicin gamma1.

K. C. Nicolaou, Angew. Chem., Int. Ed. Engl., 1993, 32, 5377.

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The total synthesis of brevetaxin B: A twelve-year odyssey in organic synthesis.

K. C. Nicolaou, Angew. Chem., Int. Ed. Engl., 1996, 35, 589.

Key Words:
BREVETOXIN B/NATURAL PRODUCTS/TOTAL SYNTHESES/BREVETOXIN-B/RING-SYSTEM/STEREOCONTROLLED SYNTHESIS/TETRAHYDROPYRAN SYSTEMS/EPOXIDE OPENINGS/HEMIBREVETOXIN-B/CONSTRUCTION/TECHNOLOGY/PALYTOXIN/DITHIATOPAZINE



Chemistry, biology, and medicine of the glycopeptide antibiotics.

K. C. Nicolaou, C. N. C. Boddy, S. Brase, N. Winssinger, Angew. Chem., Int. Ed. Engl., 1999, 38, 2097.

Key Words:
biaryls/glycopeptides/mode of action/total synthesis/vancomycin/ALPHA-AMINO-ACIDS/VANCOMYCIN-RESISTANT ENTEROCOCCI/CARBOXYLATE-BINDING POCKET/C-O-D/ALANYL-D-ALANINE/FORMAL TOTAL SYNTHESIS/NUCLEOPHILIC AROMATIC-SUBSTITUTION/ULLMANN MACROCYCLIZATION REACTION/INHIBITING GP120-CD4 BINDING/INTRAMOLECULAR SNAR REACTION



Does CIP nomenclature adequately handle molecules with multiple stereoelements? A case study of vancomycin and cognates.

K. C. Nicolaou, C. N. C. Boddy, J. S. Siegel, Angew. Chem., Int. Ed. Engl., 2001, 40, 701.

Key Words:
atropisomerism; cycloisomerism; nomenclature; stereochemistry; vancomycin; RING SKELETON; AGLYCON; STEREOISOMERISM; CHIRALITY; CONSTRUCTION; REVISION



Synthesis of novel oligosaccharides.

K. C. Nicolaou, T. J. Caulfield, R. D. Groneberg, Pure Appl. Chem., 1991, 63, 555.

Key Words:
FUNCTIONAL GROUPS/TRANSFORMATIONS/CARBOHYDRATES



Chemistry and biology of enediyne anticancer antibiotics.

K. C. Nicolaou, W.-M. Dai, Angew. Chem., Int. Ed. Engl., 1991, 30, 1387.

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Chemistry and biology of taxol.

K. C. Nicolaou, W.-M. Dai, R. K. Guy, Angew. Chem., Int. Ed. Engl., 1994, 33, 15.

Key Words:



The conquest of taxol.

K. C. Nicolaou, R. K. Guy, Angew. Chem., Int. Ed. Engl., 1995, 34, 2079.

Key Words:
NATURAL PRODUCTS/TAXOL/TOTAL SYNTHESES/CONVERGENT STRATEGY/TAXANE/VERTICILLENE/ALKALOIDS/SYSTEM



The Wittig and related reactions in natural product synthesis.

K. C. Nicolaou, M. W. Harter, J. L. Gunzner, A. Nadin, Liebigs Ann. Chem., 1997, 1283.

Key Words:
Wittig reactions/Horner/Wadsworth-Emmons/natural products/total synthesis/STEREOCONTROLLED TOTAL SYNTHESIS/IONOPHORE ANTIBIOTIC X-14547A/ENDIANDRIC ACID CASCADE/KEY BUILDING-BLOCKS/AMPHOTERICIN-B/AMPHOTERONOLIDE-B/BREVETOXIN-B/ORGANIC-SYNTHESIS/GENERATION STRATEGIES/OLEFINATION REACTION



Chemistry, Biology and Medicine of Selected Tubulin Polymerizing Agents.

K. C. Nicolaou, D. Hepworth, N. P. King, M. R. V. Finlay, Pure Appl. Chem., 1999, 71, 989.

Key Words:
Tubulin polymerizing agents Taxol Sarcodictyin



K. C. Nicolaou, N. P. King, Y. He, in Alkene Metathesis in Organic Synthesis (Ed.: A. Furstner), Springer-Verlag Berlin, Heidelberger Platz 3/W-1000 Berlin 33/Germany, 1998, pp. 73.

Key Words:
ring-closing metathesis/epothilones/Tebbe reagent/Petasis reagent/maitotoxin



Adventures in carbohydrate chemistry: New synthetic technologies, chemical synthesis, molecular design, and chemical biology.

K. C. Nicolaou, H. J. Mitchell, Angew. Chem., Int. Ed. Engl., 2001, 40, 1576.

Key Words:
carbohydrates; glycosidation; natural products; synthetic methods; total synthesis; SOLID-PHASE SYNTHESIS; 16-MEMBERED-RING MACROLIDE ANTIBIOTICS; KEY BUILDING-BLOCKS; FG RING-SYSTEM; BETA-D-GLUCOSE; TO-TAIL DIMER; BREVETOXIN-B; GLYCOSYL FLUORIDES; AMPHOTERICIN-B; STEREOCONTROLLED SYNTHESIS



The total synthesis of Amphoteronolide B and Amphotericin B.

K. C. Nicolaou, W. W. Ogilvie, Chemtracts: Organic Chemistry, 1990, 3, 327.

Key Words:
TARGET SYNTHESIS/MACROLIDES



K. C. Nicolaou, N. A. Petasis, in Strategies and Tactics in Organic Synthesis, Vol. 1 (Ed.: T. Lindberg), Academic Press, 1984.

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Lipoxins and related eicosanoids: biosynthesis, biological properties, and chemical synthesis.

K. C. Nicolaou, J. Y. Ramphal, N. A. Petasis, C. N. Serhan, Angew. Chem., Int. Ed. Engl., 1991, 30, 1100.

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Recent developments in the chemistry, biology and medicine of the epothilones.

K. C. Nicolaou, A. Ritzen, K. Namoto, J. Chem. Soc., Chem. Commun., 2001, 1523.

Key Words:
MACROLACTONIZATION-BASED STRATEGY; ENANTIOSELECTIVE TOTAL SYNTHESIS; MICROTUBULE-STABILIZING AGENTS; COMMON PHARMACOPHORE; SIDE-CHAIN; STEREOSELECTIVE SYNTHESIS; DESOXYEPOTHILONE-B; ANTITUMOR-ACTIVITY; CHEMICAL SYNTHESIS; NATURAL-PRODUCTS



Chemical biology of epothilones.

K. C. Nicolaou, F. Roschangar, D. Vourloumis, Angew. Chem., Int. Ed. Engl., 1998, 37, 2015.

Key Words:
antitumor agents/epothilones/natural products/structure-activity relationships/total synthesis/RING-CLOSING METATHESIS/MICROTUBULE DYNAMIC INSTABILITY/OLEFIN METATHESIS/NATURAL-PRODUCTS/PACLITAXEL TAXOL/SIGNAL-TRANSDUCTION/MACROLACTONIZATION APPROACH/KINETIC STABILIZATION/ASYMMETRIC-SYNTHESIS/ORGANIC-SYNTHESIS



Molecular design, chemical synthesis, and biological action of enediynes.

K. C. Nicolaou, A. L. Smith, Acc. Chem. Res., 1992, 25, 497.

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Progress towards the total synthesis of the ene-diyne anticancer antibiotics.

K. C. Nicolaou, A. L. Smith, Pure Appl. Chem., 1993, 65, 1271.

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K. C. Nicolaou, A. L. Smith, in Modern Acetylene Chemistry (Eds.: P. J. Stang, F. Diederich), V C H Verlagsgesellschaft, Weinheim, Germany, 1995, pp. 203.

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Synthesis of DNA-binding oligosaccharides.

K. C. Nicolaou, B. M. Smith, J. Pastor, Y. Watanabe, D. S. Weinstein, Synlett, 1997, 401.

Key Words:
oligosaccharide/DNA-binding/CALICHEAMICIN OLIGOSACCHARIDE/ANTITUMOR ANTIBIOTICS/DUPLEX DNA/DOMAIN/CALICHEMICIN-GAMMA-1/GAMMA-1(I)/CHEMISTRY/CLEAVAGE/FAMILY



The Diels-Alder reaction in total synthesis

K. C. Nicolaou, S. A. Snyder, T. Montagnon, G. Vassilikogiannakis, Angew. Chem., Int. Ed. Engl., 2002, 41, 1668.

Key Words:
biomimetic synthesis/cycloaddition/Diels-Alder reaction/molecular diversity/total synthesis/FORMAL TOTAL SYNTHESIS/ENANTIOSELECTIVE TOTAL SYNTHESIS/IONOPHORE ANTIBIOTIC X-14547A/BIOMIMETIC TOTAL SYNTHESIS/STEREOCONTROLLED TOTAL SYNTHESIS/STEREOSPECIFIC TOTAL SYNTHESIS/ASYMMETRIC TOTAL SYNTHESIS/HYDROXY-O-QUINODIMETHANES/CP MOLECULES CP-263,114/ENDIANDRIC ACID CASCADE



K. C. Nicolaou, E. J. Sorensen, Classics in Total Synthesis. Targets, Strategies, Methods., VCH, Weinheim, 1996.

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Chemistry and biology of selected natural products.

K. C. Nicolaou, E. A. Theodorakis, C. F. Claiborne, Pure Appl. Chem., 1996, 68, 2129.

Key Words:
PROTEIN-KINASE-C/BREVETOXIN-B/SQUALENE SYNTHASE/ANTITUMOR ANTIBIOTICS/ZARAGOZIC ACIDS/TAXOL/RAPAMYCIN/INHIBITORS/BINDING/FAMILY



K. C. Nicolaou, H. Ueno, in Preparative Carbohydrate Chemistry (Ed.: S. Hanessian), Marcel Dekker, 270 Madison Ave/New York/NY 10016, 1997, pp. 313.

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The art and science of total synthesis at the dawn of the twenty-first century.

K. C. Nicolaou, D. Vourloumis, N. Winssinger, P. S. Baran, Angew. Chem., Int. Ed. Engl., 2000, 39, 45.

Key Words:
drug research/natural products/synthetic methods/total synthesis/ENANTIOSELECTIVE TOTAL SYNTHESIS/FORMAL TOTAL SYNTHESIS/BETA-LACTAM ANTIBIOTICS/STEREOSPECIFIC TOTAL SYNTHESIS/ASYMMETRIC TOTAL SYNTHESIS/STEREOCONTROLLED TOTAL SYNTHESIS/SPONGE THEONELLA-SWINHOEI/DIELS-ALDER REACTION/TEMPORARY SILICON CONNECTION/MARINE TOXIC POLYETHERS