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Mild and efficient method for the cleavage of benzylidene acetals by using erbium (III) triflate

Antonio Procopio*, Renato Dalpozzo, Antonio De Nino, Loredana Maiuolo, Monica Nardi and Giovanni Romeo

*Dipartimento die Scienze Farmaco-Biologiche, Università della Magna Greacia, Complesso Ninì Barbieri, 88021 Rocelletta di Borgia (Cz), Italy, Email: procopiounicz.it

A. Procopio, R. Dalpozzo, A. De Nino, L. Maiuolo, M. Nardi, G. Romeo, Org. Biomol. Chem., 2005, 3, 4129-4133.

DOI: 10.1039/b511314h


Abstract

Er(OTf)3 is an efficient Lewis acid catalyst in a mild deprotection of benzylidene derivatives. A simultaneous cleavage of benzylidene acetals and peracetylation of the substrates is obtained in quantitative yields in acetic anhydride as solvent.

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Er(OTf)3 as a Mild Cleaving Agents for Acetals and Ketals

R. Dalpozzo, A. De Nino, L. Maiuolo, M. Nardi, A. Procopio, A. Tagarelli, Synthesis, 2004, 496-498.


Key Words

Benzylidene Acetal, Deprotection, Acylation


ID: J52-Y2005-1780