IBX-Mediated α-Hydroxylation of α-Alkynyl Carbonyl Systems. A Convenient Method for the Synthesis of Tertiary Alcohols

Stefan F. Kirsch*

*Department Chemie, Technische Universität München, Lichtenbergstr. 4, D-85747 Garching, Germany, Email: stefan.kirschch.tum.de

S. F. Kirsch, J. Org. Chem., 2005, 70, 10210-10212.

DOI: 10.1021/jo051898j (free Supporting Information)

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Abstract

The α-hydroxylation of α-alkynyl carbonyl compounds using IBX (o-iodoxybenzoic acid) gave various tertiary alcohols without dehydrogenation products under mildly acidic conditions.

see article for more reactions

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Gold(III)- and Platinum(II)-Catalyzed Domino Reaction Consisting of Heterocyclization and 1,2-Migration: Efficient Synthesis of Highly Substituted 3(2H)-Furanones

S. F. Kirsch, J. T. Binder, C. Liébert, H. Menz, Angew. Chem. Int. Ed., 2006, 45, 5878-5880.

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Key Words

IBX, α-Hydroxylation

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ID: J42-Y2005-2010