Multicomponent One-Pot Procedure for the Synthesis of Free α-Chiral Amines from Aldehydes
Alexandre Côté and André B. Charette*
*Département de Chimie, Université de Montréal, P.O. 6128, Station Downtown,
Montréal, Québec, Canada H3C 3J7, Email: andre.charette
umontreal.ca
A. Cote, A. B. Charette, J. Org. Chem., 2005, 70, 10864-10867.
DOI: 10.1021/jo0516483 (free Supporting Information)
Abstract
The synthesis of free α-chiral amines by a one-pot multicomponent procedure involves the formation of N-diphenylphosphinoylimines from commercially available starting materials and the subsequent enantioselective addition of diakylzinc reagents using an air-stable precatalyst complex.
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Key Words
Primary Amines, Addition, Benzylamines, Multicomponent Reactions
ID: J48-Y2005-2110
