'In situ'; Generated 'HCl'; - An Efficient Catalyst for Solvent-Free Hantzsch Reaction at Room Temperature: Synthesis of New Dihydropyridine Glycoconjugates
G. V. M. Sharma*, K. Laxmi Reddy, P. Sree Lakshmi, Palakodety Radha Krishna
*D-211, Discovery Laboratory, Organic Chemistry Division-III, Indian
Institute of Chemical Technology, Hyderabad-500 007, India,
Email: esmvee
iict.res.in
G. V. M. Sharma, K. L. Reddy, P. S. Lakshmi, P. R. Krishna, Synthesis, 2006, 55-58.
DOI: 10.1055/s-2005-921744
Abstract
HCl, generated in situ from 2,4,6-trichloro[1,3,5]triazine (TCT, cyanuric chloride), catalyzed a solvent free Hantzsch reaction at room temperature with enhanced reaction rates. The reaction conditions allow facile preparation of glycoconjugates of dihydropyridines under mild reaction conditions in high yields.
see article for more examples
Key Words
dihydropyridines, glycoconjugates, Hantzsch reaction, 2,4,6-trichloro[1,3,5]triazine (TCT - cyanuric chloride)
ID: J66-Y2006-060
