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Modified Palladium-Catalyzed Sonogashira Cross-Coupling Reactions under Copper-, Amine-, and Solvent-Free Conditions

Yun Liang, Ye-Xiang Xie and Jin-Heng Li*

*Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China, jhlihunnu.edu.cn

Y. Liang, Y.-X. Xie, J.-H. Li, J. Org. Chem., 2006, 71, 379-381.

DOI: 10.1021/jo051882t (free Supporting Information)


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Abstract

A fast Sonogashira reaction of various aryl halides (X=I, Br, Cl) with alkynes in the presence of 3 mol% of PdCl2(PPh3)2 and 3 eq. of TBAF under copper-, amine-, and solvent-free conditions afforded the coupled products in moderate to excellent yields.

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Key Words

Sonogashira Coupling


ID: J42-Y2006-120