Organic Chemistry Portal

Abstracts

Search:

Expedited Palladium-Catalyzed Amination of Aryl Nonaflates through the Use of Microwave-Irradiation and Soluble Organic Amine Bases

Rachel E. Tundel, Kevin W. Anderson and Stephen L. Buchwald*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, sbuchwalmit.edu

R. E. Tundel, K. W. Anderson, S. L. Buchwald, J. Org. Chem., 2006, 71, 430-433.

DOI: 10.1021/jo052131u (free Supporting Information)


see article for more examples

Abstract

Microwave-assisted, palladium-catalyzed C-N bond-forming reactions with aryl/heteroaryl nonaflates and amines using soluble amine bases resulted in good to excellent yields of arylamines in short reaction times.

see article for more examples

see article for more reactions



Key Words

Microwave Synthesis, Buchwald-Hartwig Coupling, Arylamines, Amidation


ID: J42-Y2006-120