High Performance of Rh(Phebox) Catalysts in Asymmetric Reductive Aldol Reaction: High Anti-Selectivity
Hisao Nishiyama,* Takushi Shiomi, Yasunori Tsuchiya and Isamu Matsuda
*Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603, Japan, Email: hnishiapchem.nagoya-u.ac.jp
H. Nishiyama, T. Shiomi, Y. Tsuchiya, I. Matsuda, J. Am. Chem. Soc., 2005, 127, 6972-6973.
DOI: 10.1021/ja050698m
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Abstract
Chiral rhodium(bisoxazolinylphenyl) complexes efficiently catalyze the asymmetric reductive aldol reaction of aldehydes and α,β-unsaturated esters with hydrosilanes to give the corresponding β-hydroxypropionates with high anti-selectivity and enantioselectivity. The selectivity is discussed.
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K. Itoh, A. Tsuruta, J.-i. Ito, Y. Yamamoto, H. Nishiyama, J. Org. Chem., 2012, 77, 10914-10919.
Conjugate Reduction of α,β-Unsaturated Aldehydes with Rhodium(bisoxazolinylphenyl) Catalysts
Y. Kanazawa, H. Nishiyama, Synlett, 2006, 3343-3345.
Key Words
β-Hydroxy Esters, Reductive Aldol Reaction
ID: J48-Y2005-2360