Construction of Quaternary Stereocenters by Efficient and Practical Conjugate Additions to α,β-Unsaturated Ketones with a Chiral Organic Catalyst
Fanghui Wu, Hongming Li, Ran Hong, Li Deng*
*Department of Chemistry, Brandeis University, Waltham, MA 02454-9110, USA, E-mail:
deng
brandeis.edu
F. Wu, H. Li, R. Hong, L. Deng, Angew. Chem. Int. Ed., 2006, 45, 947-950.
DOI: 10.1002/anie.200502658 (free Supporting Information)
see article for more reactions
Abstract
Easily accessible chiral organic catalysts mediated a highly efficient and general conjugate addition of α-substituted β-ketoesters to α,β-unsaturated ketones.
see article for more examples
Key Words
Active Methylenes, Michael Addition, Organocatalysis, Alkaloids, Conjugate Addition, Diastereoselectivity, Enantioselectivity, Enones
ID: J06-Y2006-220
