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Construction of Quaternary Stereocenters by Efficient and Practical Conjugate Additions to α,β-Unsaturated Ketones with a Chiral Organic Catalyst

Fanghui Wu, Hongming Li, Ran Hong, Li Deng*

*Department of Chemistry, Brandeis University, Waltham, MA 02454-9110, USA, E-mail: dengbrandeis.edu

F. Wu, H. Li, R. Hong, L. Deng, Angew. Chem. Int. Ed., 2006, 45, 947-950.

DOI: 10.1002/anie.200502658 (free Supporting Information)



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Abstract

Easily accessible chiral organic catalysts mediated a highly efficient and general conjugate addition of α-substituted β-ketoesters to α,β-unsaturated ketones.

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Key Words

Active Methylenes, Michael Addition, Organocatalysis, Alkaloids, Conjugate Addition, Diastereoselectivity, Enantioselectivity, Enones


ID: J06-Y2006-220