A Versatile Method for Suzuki Cross-Coupling Reactions of Nitrogen Heterocycles
Noriaki Kudo, Mauro Perseghini, Gregory C. Fu
*Department of Chemistry, Massachusetts Institute of Technology, Cambridge,
MA 02139, USA, Email: gcf
mit.edu
N. Kudo, M. Perseghini, G. C. Fu, Angew. Chem. Int. Ed., 2006, 45, 1282-1284.
DOI: 10.1002/anie.200503479 (free Supporting Information)
Abstract
A versatile Suzuki reaction of nitrogen-containing heterocyclic cross-coupling partners was developed. The method allowed the conversion of boronic acids, boronates, trifluoroborates even with unactivated aryl chlorides and tolerated various unprotected functionalities including NH2- and OH-substituted pyridines and indoles
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Key Words
Suzuki Coupling, N-Heterocycles, homogeneous catalysis, nitrogen, palladium
ID: J06-Y2006-320
