Ni(II)-Bis[(R,R)-N,N'-dibenzylcyclohexane-1,2-diamine]Br₂ Catalyzed Enantioselective Michael Additions of 1,3-Dicarbonyl Compounds to Conjugated Nitroalkenes

David A. Evans* and Daniel Seidel

*Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, Email: evanschemistry.harvard.edu

D. A. Evans, D. Seidel, J. Am. Chem. Soc., 2005, 127, 9958-9959.

DOI: 10.1021/ja052935r

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Abstract

A Ni(II)-(bis)diamine-catalyzed, highly enantioselective Michael addition of substituted and unsubstituted malonates and β-ketoesters to nitroalkenes bearing aromatic and aliphatic residues has been developed.

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Key Words

Michael Addition, Nitro Compounds

ID: J48-Y2005-2450

Ni(II)-Bis[(R,R)-N,N'-dibenzylcyclohexane-1,2-diamine]Br2 Catalyzed Enantioselective Michael Additions of 1,3-Dicarbonyl Compounds to Conjugated Nitroalkenes

David A. Evans* and Daniel Seidel

Ni(II)-Bis[(R,R)-N,N'-dibenzylcyclohexane-1,2-diamine]Br₂ Catalyzed Enantioselective Michael Additions of 1,3-Dicarbonyl Compounds to Conjugated Nitroalkenes