Cycloisomerization of Enynes via Rhodium Vinylidene-Mediated Catalysis
Hahn Kim and Chulbom Lee*
*Department of Chemistry, Princeton University, Princeton, New Jersey 08544, Email: cbleeprinceton.edu
H. Kim, C. Lee, J. Am. Chem. Soc., 2005, 127, 10180-10181.
DOI: 10.1021/ja052775j (free Supporting Information)
A rhodium-catalyzed cycloisomerization converts various acyclic enynes to their cyclic diene isomers with endoselectivity. Two different catalyst systems have been developed, which are effective in promoting the C-C bond-forming cyclization of enynes to furnish carbo- and heterocycles in good to excellent yield. The mechanism is discussed.
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