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A New Synthetic Approach to Phenol Derivatives: Use of Ring-Closing Olefin Metathesis

Kazuhiro Yoshida* and Tsuneo Imamoto*

*Department of Chemistry, Faculty of Science, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan, Email: kyoshidafaculty.chiba-u.jp, imamotofaculty.chiba-u.jp

K. Yoshida, T. Imamoto, J. Am. Chem. Soc., 2005, 127, 10470-10471.

DOI: 10.1021/ja050853x (free Supporting Information)



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Abstract

Phenol derivatives were synthesized by ruthenium-catalyzed ring-closing metathesis of various 1,4,7-trien-3-ones and 1,5,7-trien-3-one as another precursor. Most of the phenols prepared could not be obtained easily by conventional methods.

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An Efficient Route to Benzene and Phenol Derivatives via Ring-Closing Olefin Metathesis

K. Yoshida, S. Horiuchi, N. Iwadate, F. Kawagoe, T. Imamoto, Synlett, 2007, 1561-1562.

Synthesis of 3-Hydroxypyridines Using Ruthenium-Catalyzed Ring-Closing Olefin Metathesis

K. Yoshida, F. Kawagoe, K. Hayashi, S. Horiuchi, T. Imamoto, A. Yanagisawa, Org. Lett., 2009, 11, 515-518.


Key Words

Ring-closing metathesis, Phenols, Cyclizations


ID: J48-Y2005-2480