Catalytic Enantioselective Negishi Reactions of Racemic Secondary Benzylic Halides
Forrest O. Arp and Gregory C. Fu*
*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email: gcfmit.edu
F. O. Arp, G. C. Fu, J. Am. Chem. Soc., 2005, 127, 10482-10483.
DOI: 10.1021/ja053751f (free Supporting Information)
An enantioselective nickel-catalyzed Negishi cross-coupling of racemic secondary benzylic bromides and chlorides is described. The catalyst components are commercially available and air-stable, and the reaction is not highly oxygen- or moisture-sensitive.
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