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Catalytic Enantioselective Negishi Reactions of Racemic Secondary Benzylic Halides

Forrest O. Arp and Gregory C. Fu*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email:

F. O. Arp, G. C. Fu, J. Am. Chem. Soc., 2005, 127, 10482-10483.

DOI: 10.1021/ja053751f (free Supporting Information)


An enantioselective nickel-catalyzed Negishi cross-coupling of racemic secondary benzylic bromides and chlorides is described. The catalyst components are commercially available and air-stable, and the reaction is not highly oxygen- or moisture-sensitive.

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Key Words

Negishi Coupling, Benzylation, Indanes

ID: J48-Y2005-2510