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Hydrogen Bond Catalyzed Direct Reductive Amination of Ketones

Dirk Menche,* Jorma Hassfeld, Jun Li, Gerd Menche, Antje Ritter and Sven Rudolph

*Gesellschaft für Biotechnologische Forschung mbH, Medzinische Chemie, Mascheroder Weg 1, D-38124 Braunschweig, Germany, Email: dme05gbf.de

D. Menche, J. Hassfeld, J. Li, G. Menche, A. Ritter, S. Rudolph, Org. Lett., 2006, 8, 741-744.

DOI: 10.1021/ol053001a (free Supporting Information)


Abstract

A biomimetic direct reductive amination of ketones relies on selective imine activation by hydrogen bond formation with thiourea as hydrogen bond donor and utilizes the Hantzsch ester for transfer hydrogenation. The method allows the efficient synthesis of structurally diverse amines.

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Thiourea-Catalyzed Direct Reductive Amination of Aldehydes

D. Menche, F. Arikan, Synlett, 2006, 841-844.


Key Words

reductive amination, Hantzsch ester, organocatalysis


ID: J54-Y2006-550