Asymmetric Alkynylation of Aldehydes Catalyzed by an In(III)/BINOL Complex
Ryo Takita, Kenichiro Yakura, Takashi Ohshima and Masakatsu Shibasaki*
*Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo,
Bunkyo-ku, Tokyo 113-0033, Japan, Email: mshibasa
mol.f.u-tokyo.ac.jp
R. Takita, K. Yakura, T. Ohshima, M. Shibasaki, J. Am. Chem. Soc., 2005, 127, 13760-13761.
DOI: 10.1021/ja053946n
Abstract
Asymmetric alkynylation of aldehydes using catalytic amounts of In(III)/BINOL enables a broad range of substrate generality with high enantioselectivity due to the "bifunctional character" of the catalyst activating both substrates.
see article for more examples
Key Words
ID: J48-Y2005-2590
