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Supramolecular Catalysis of Strecker Reaction in Water under Neutral Conditions in the Presence of β-Cyclodextrin

K. Surendra, N. Srilakshmi Krishnaveni, A. Mahesh and K. Rama Rao*

*Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500 007, India, Email: drkrraoyahoo.com

K. Surendra, N. S. Krishnaveni, A. Mahesh, K. R. Rao, J. Org. Chem., 2006, 71, 2532-2534.

DOI: 10.1021/jo052510n (free Supporting Information)


Abstract

An environmentally benign and highly efficient, biomimetic procedure for the nucleophilic addition of trimethylsilyl cyanide to imines (Strecker reaction) using β-cyclodextrin as a catalyst and water as solvent afforded α-aminonitriles in quantitative yields. The catalyst can be recycled a number of times without loss in activity.

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Key Words

Strecker Synthesis, α-Aminonitriles, Trimethylsilyl Cyanide


ID: J42-Y2006-810