Organic Chemistry Portal

Abstracts

Search:

Direct Catalytic Intermolecular α-Allylic Alkylation of Aldehydes by Combination of Transition-Metal and Organocatalysis

Ismail Ibrahem, Armando Córdova*

*Department of Organic Chemistry, The Arrhenius Laboratory, Stockholm University, 106 91 Stockholm, Sweden, Email: acordovaorgan.su.se

I. Ibrahem, A. Córdova, Angew. Chem. Int. Ed., 2006, 45, 1952-1956.

DOI: 10.1002/anie.200504021 (free Supporting Information)


see article for more examples

Abstract

A simple method for the chemo- and regioselective, direct catalytic allylic alkylation of aldehydes and cyclic ketones has been developed. The combination of palladium and enamine catalysis furnished α-allylic alkylated aldehydes and cyclic ketones in high yields.

see article for more examples



Key Words

aldehydes, allylation, substituted alcohols, organocatalysis, sodium borohydride, Tsuji-Trost Reaction


ID: J06-Y2006-830