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Efficient Copper-Free PdCl2(PCy3)2-Catalyzed Sonogashira Coupling of Aryl Chlorides with Terminal Alkynes

Chenyi Yi and Ruimao Hua*

*Department of Chemistry, Tsinghua University, Innovative Catalysis Program, Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Beijing 100084, Email: ruimaomail.tsinghua.edu.cn

C. Yi, R. Hua, J. Org. Chem., 2006, 71, 2535-2537.

DOI: 10.1021/jo0525175 (free Supporting Information)


Abstract

PdCl2(PCy3)2-catalyzed copper-free cross-coupling of electron-rich, electron-neutral, and electron-deficient aryl chlorides with a variety of terminal alkynes afforded internal arylated alkynes in good to excellent yields with Cs2CO3 as a base in DMSO at 100-120C.

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Key Words

Sonogashira Coupling


ID: J42-Y2006-860