Efficient Copper-Free PdCl2(PCy3)2-Catalyzed Sonogashira Coupling of Aryl Chlorides with Terminal Alkynes
Chenyi Yi and Ruimao Hua*
*Department of Chemistry, Tsinghua University, Innovative Catalysis Program,
Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of
Education, Beijing 100084, Email: ruimao
mail.tsinghua.edu.cn
C. Yi, R. Hua, J. Org. Chem., 2006, 71, 2535-2537.
DOI: 10.1021/jo0525175 (free Supporting Information)
Abstract
PdCl2(PCy3)2-catalyzed copper-free
cross-coupling of electron-rich, electron-neutral, and electron-deficient aryl
chlorides with a variety of terminal alkynes afforded internal arylated alkynes
in good to excellent yields with Cs2CO3 as a base in DMSO
at 100-120°C.
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Key Words
ID: J42-Y2006-860
