Reusable and Efficient Pd(OAc)2/TBAB/PEG-400 System for Suzuki-Miyaura Cross-Coupling Reaction under Ligand-Free Conditions
Wen-Jie Liu, Ye-Xiang Xie, Yun Liang, Jin-Heng Li*
*College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, P. R. of China, Email: jhlihunnu.edu.cn
W.-J. Liu, Y.-X. Xie, Y. Liang, J.-H. Li, Synthesis, 2006, 860-864.
The combination of Pd(OAc)2, TBAB and PEG-400 [poly(ethylene glycol-400)] was introduced as a reusable, ligand-free and efficient system for the Suzuki-Miyaura cross-coupling reaction. The coupling of a number of aryl halides with arylboronic acids afforded the corresponding products in moderate to excellent yields.
see article for more examples
J.-H. Li, W.-J. Liu, Y.-X. Xie, J. Org. Chem., 2005, 70, 5409-5412.