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Mild Organocatalytic α-Methylenation of Aldehydes

Anniina Erkkilä and Petri M. Pihko*

*Laboratory of Organic Chemistry, Helsinki University of Technology, P.O.B. 6100, FI-02015 TKK, Finland, Email: petri.pihkotkk.fi

A. Erkkilä, P. M. Pihko, J. Org. Chem., 2006, 71, 2538-2541.

DOI: 10.1021/jo052529q (free Supporting Information)


Abstract

Two optimal catalytic systems for the convenient and fast α-methylenation of aldehydes with aqueous formaldehyde are described that allow short reaction times and afford the methylenated products in good to excellent yields and chemoselectivity.

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Key Words

Enones, Methylenation, Organocatalysis


ID: J42-Y2006-860