A Facile and Efficient Direct Aldol Addition of Simple Thioesters
Julianne M. Yost, Guoqiang Zhou and Don M. Coltart*
*Department of Chemistry, Duke University, Durham, North Carolina 27708, Email: don.coltartduke.edu
J. M. Yost, G. Zhou, D. M. Coltart, Org. Lett., 2006, 8, 1503-1506.
DOI: 10.1021/ol060413q (free Supporting Information)
Simple thioesters undergo direct aldol addition to aldehydes in the presence of a Lewis acid and i-Pr2NEt. The reactions proceed extremely rapidly and in excellent yield.
see article for more examples
G. Zhou, D. Lim, D. M. Coltart, Org. Lett., 2008, 10, 3809-3812.