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Facile N-Arylation of Amines and Sulfonamides and O-Arylation of Phenols and Arenecarboxylic Acids

Zhijian Liu and Richard C. Larock*

*Department of Chemistry, Iowa State University, Ames, Iowa 50011, Email: larockiastate.edu

Z. Liu, R. C. Larock, J. Org. Chem., 2006, 71, 3198-3209.

DOI: 10.1021/jo0602221 (free Supporting Information)


Abstract

An efficient, mild and transition-metal-free N-arylation of amines, sulfonamides, and carbamates and O-arylation of phenols and carboxylic acids has been achieved by using various o-silylaryl triflates in the presence of CsF.

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Key Words

Arylation (Arylamines, Sulfonamides, Phenols, Thiophenols, Carboxylic Acids)


ID: J42-Y2006-980