Regioselective Copper-Catalyzed Amination of Bromobenzoic Acids Using Aliphatic and Aromatic Amines
Christian Wolf,* Shuanglong Liu, Xuefeng Mei, Adam T. August, and Michael D. Casimir
*Department of Chemistry, Georgetown University, Washington, D.C. 20057, Email: cw27georgetown.edu
C. Wolf, S. Liu, X. Mei, A. T. August, M. D. Casimir, J. Org. Chem., 2006, 71, 3270-3273.
DOI: 10.1021/jo060034a (free Supporting Information)
A chemo- and regioselective copper-catalyzed amination of 2-bromobenzoic acids is described, which avoids the need for acid protection and produces N-aryl and N-alkyl anthranilic acid derivatives in good yield.
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