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Traditional Morita-Baylis-Hillman reaction of aldehydes with methyl vinyl ketone co-catalyzed by triphenylphosphine and nitrophenol

Min Shi* and Ying-Hao Liu

*State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China, Email: mshipub.sioc.ac.cn

M. Shi, Y.-H. Liu, Org. Biomol. Chem., 2006, 4, 1468-1470.

DOI: 10.1039/b600854b (free Supporting Information)


Abstract

The triphenylphosphine-catalyzed Morita-Baylis-Hillman reaction of aldehydes with methyl vinyl ketone is effectively promoted in the presence of a catalytic amount of phenol to give the corresponding Morita-Baylis-Hillman adducts in good yields. The mechanism is discussed.

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Key Words

Baylis-Hillman reaction


ID: J52-Y2006-1000