(Bromodimethyl)sulfonium Bromide Catalyzed One-Pot Synthesis of α-Aminonitriles
Biswanath Das*, R. Ramu, B. Ravikanth, K. Ravinder Reddy
*Organic Chemistry Division I, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Email: biswanathdasyahoo.com
B. Das, R. Ramu, B. Ravikanth, K. Ravinder Reddy, Synthesis, 2006, 1419-1422.
A novel, simple and efficient one-pot synthesis of α-aminonitriles has been achieved by a three-component condensation of carbonyl compounds, amines and trimethylsilyl cyanide in the presence of (bromodimethyl)sulfonium bromide as a catalyst at room temperature.
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