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Triazole-Based Monophosphine Ligands for Palladium-Catalyzed Cross-Coupling Reactions of Aryl Chlorides

Qian Dai, Wenzhong Gao, Duan Liu, Lea M. Kapes and Xumu Zhang*

*Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, Email: xumuchem.psu.edu

Q. Dai, W. Gao, D. Liu, L. M. Kapes, X. Zhang, J. Org. Chem., 2006, 71, 3928-3934.

DOI: 10.1021/jo060321e (free Supporting Information)



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Abstract

Various triazole-based monophosphines (ClickPhos) have been prepared via efficient 1,3-dipolar cycloaddition. Their palladium complexes provided provided excellent yields in amination reactions and Suzuki-Miyaura coupling reactions of unactivated aryl chlorides.

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Triazole-Based Monophosphines for Suzuki-Miyaura Coupling and Amination Reactions of Aryl Chlorides

D. Liu, W. Gao, Q. Dai, X. Zhang, Org. Lett., 2005, 7, 4907-4910.


Key Words

1,2,3-Triazoles, Suzuki Coupling, Buchwald-Hartwig Coupling, Biaryl Synthesis, Aryl Amines


ID: J42-Y2006-1260