Enantioselective Nitroaldol Reaction of α-Ketoesters Catalyzed by Cinchona Alkaloids
Hongming Li, Baomin Wang and Li Deng*
*Department of Chemistry, Brandeis University, Waltham, Massachusetts 02454-9110, Email: dengbrandeis.edu
H. Li, B. Wang. L. Deng, J. Am. Chem. Soc., 2006, 128, 732-733.
DOI: 10.1021/ja057237l (free Supporting Information)
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C6'-OH cinchona alkaloid-catalyzed asymmetric nitroaldol reactions with α-ketoesters are highly efficient, operationally simple, and afford high enantioselectivity as well as good to excellent yield for a broad range of α-ketoesters.
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