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Enantioselective Nitroaldol Reaction of α-Ketoesters Catalyzed by Cinchona Alkaloids

Hongming Li, Baomin Wang and Li Deng*

*Department of Chemistry, Brandeis University, Waltham, Massachusetts 02454-9110, Email: dengbrandeis.edu

H. Li, B. Wang. L. Deng, J. Am. Chem. Soc., 2006, 128, 732-733.

DOI: 10.1021/ja057237l (free Supporting Information)


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Abstract

C6'-OH cinchona alkaloid-catalyzed asymmetric nitroaldol reactions with α-ketoesters are highly efficient, operationally simple, and afford high enantioselectivity as well as good to excellent yield for a broad range of α-ketoesters.

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Key Words

Henry Reaction, Addition, Nitro Compounds, Organocatalysis


ID: J48-Y2006-1270