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A facile and chemoselective conjugate reduction using polymethylhydrosiloxane (PMHS) and catalytic B(C6F5)3

Srivari Chandrasekhar*, Gudise Chandrashekar, Marepally Srinivasa Reddy and Pabbaraja Srihari

*Organic Division-1, Indian Institute of Chemical Technology, Hyderabad, 500007, India, Email: srivariciict.res.in

S. Chandrasekhar, G. Chandrasekhar, M. S. Reddy, P. Srihari, Org. Biomol. Chem., 2006, 4, 1650-1652.

DOI: 10.1039/b603610b (free Supporting Information)


Abstract

A highly chemoselective conjugate reduction of electron-deficient Michael acceptors, including α,β-unsaturated ketones, carboxylic esters, nitriles and nitro compounds with PMHS in the presence of a catalytic amount of B(C6F5)3 is described.

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Key Words

Reduction of α,β-unsaturated compounds, Polymethylhydrosiloxane


ID: J52-Y2006-1280