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A facile and highly efficient route to α-amino phosphonates via three-component reactions catalyzed by Mg(ClO4)2 or molecular iodine

Jie Wu*, Wei Sun, Hong-Guang Xia and Xiaoyu Sun

*Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China, Email: jie_wufudan.edu.cn

J. Wu, W. Sun, H.-G. Xia, X. Sun, Org. Biomol. Chem., 2006, 4, 1663-1666.

DOI: 10.1039/b602536f (free Supporting Information)


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Abstract

Three-component reactions of aldehydes, amines, and diethyl phosphite catalyzed by Mg(ClO4)2 or molecular iodine afforded the corresponding α-amino phosphonates in excellent yields under mild reaction conditions.

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Key Words

α-amino phosphonates, Kabachnik-Fields reaction, multicomponent reactions


ID: J52-Y2006-1000