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Catalytic Four-Component Assembly Based on Allenylboronate Platform: New Access to Privileged Allylic Amine Structures

Keisuke Tonogaki, Kenichiro Itami and Jun-ichi Yoshida*

*Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan, Email: yoshidasbchem.kyoto-u.ac.jp

K. Tonogaki, K. Itami, J.-I. Yoshida, J. Am. Chem. Soc., 2006, 128, 1464-1465.

DOI: 10.1021/ja057778a (free Supporting Information)


Abstract

Privileged allylic amine structures can be constructed in a regioselective, stereoselective, and diversity-oriented manner by a novel palladium-catalyzed four-component assembly based on allenylboronate platform. A short synthesis of rolipram is also demonstrated.

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Key Words

Allylic Amines, Arylation, Suzuki Coupling, Multicomponent Reactions


ID: J48-Y2006-1470