A General and Versatile Method for CC Cross-Coupling Synthesis of Conjugated Enynes: One-Pot Sequence Starting from Carbonyl Compounds
Ilya M. Lyapkalo, Michael A. K. Vogel
*Institute of Organic Chemistry and Biochemistry, Academy of
Sciences of the Czech Republic, Flemingovo n. 2, 166 10 Prague 6, Czech Republic, Email:
ilya.lyapkalo
uochb.cas.cz
I. M. Lyapkalo, M. A. K. Vogel, Angew. Chem. Int. Ed., 2006, 45, 4019-4023.
DOI: 10.1002/anie.200504594
see article for more reactions
Abstract
A straightforward one-pot approach to highly diverse conjugated enynes, starting from carbonyl precursors has been developed. The low nucleophilic phosphazene bases, which are used for the generation of the alkenyl nonaflates and the terminal alkynes, are compatible with NfF and do not impede the subsequent Sonogashira reaction.
see article for more examples
A General One-Step Synthesis of Alkynes from Enolisable Carbonyl Compounds
I. M. Lyapkalo, M. A. K. Vogel, E. V. Boltukhina, J. Vavřík, Synlett, 2009, 558-561.
Key Words
Sonogashira coupling, cross-coupling, enynes, homogeneous catalysis, phosphazene bases
ID: J06-Y2006-1560
