A General and Versatile Method for CC Cross-Coupling Synthesis of Conjugated Enynes: One-Pot Sequence Starting from Carbonyl Compounds
Ilya M. Lyapkalo, Michael A. K. Vogel
*Institute of Chemical & Engineering Sciences, 1 Pesek Road, Jurong Island,
Singapore 627833, Singapore, Email: ilya_lyapkalo
ices.a-star.edu.sg
I. M. Lyapkalo, M. A. K. Vogel, Angew. Chem. Int. Ed., 2006, 45, 4019-4023.
DOI: 10.1002/anie.200504594 (free Supporting Information)
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Abstract
A straightforward one-pot approach to highly diverse conjugated enynes, starting from carbonyl precursors has been developed. The low nucleophilic phosphazene bases, which are used for the generation of the alkenyl nonaflates and the terminal alkynes, are compatible with NfF and do not impede the subsequent Sonogashira reaction.
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Key Words
Sonogashira coupling, cross-coupling, enynes, homogeneous catalysis, phosphazene bases
ID: J06-Y2006-1560
